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Figure 1. Flow diagram of patient population in the study.
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"The novelty of this work is the new molecule we have synthesized by icariin," Dell'Agli said. "It is derived by chemical modifications of the structure of icariin, which is the active ingredient purified from E. brevicornum (horny goat weed). The mechanism by which the molecule we have found might work in humans is the inhibition of phosphodiesterase 5 (PDE 5) in the corpus cavernosum [erectile tissue in the penis], which is the mechanism by which Viagra works. This is an in vitro study. It can be considered a pre-clinical study."
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The team focused on a form of radiation therapy called intensity-modulated radiation therapy (IMRT). According to the American Cancer Society, IMRT is a cutting-edge, 3-D form of high-dose radiation therapy. The treatment is delivered by a computer-controlled machine that moves around the patient to target diseased tissue while avoiding healthy tissue, thereby allowing for the safer use of higher doses of radiation.
This work was supported by National Institutes of Health Grant DK21723 (to J.B.) and the University of Washington Cardiovascular Pathology Training Grant NIH HL-07312 (to A.B.).
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